CRF2 Cleanroom Fogger


CleanRoom Fogger SOP

The CRF2 CleanRoom Fogger is a low cost, ultrasonic fogger using 9 high performance, piezo devices to create 0.26 cubic meters per minute (9 cubic feet per minute) of pure fog with a fog density of 57 ml fog density per minute for a typical 50 minute operation. This provides about 7-8 feet of visual fog for for smoke studies and air flow characterization in small areas such as fume hoods and bio-safety cabinets. The CRF2 is compatible with USP 797 Pharmaceutical In-situ Airflow Analysis; USP 800 Compound Pharmacy airflow tests; Airflow Recovery Tests in ISO 14644-3 Annex B12; Airflow Visualization Tests for ISO 14644-3 Annex B7; NSF 49 for Bio-Safety Cabinets; and Semi-Standards Clean Room Guidelines, Federal Standard 209E.

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Cleanroom Fogger, CRF2, producing 9 cfm of fog for 50 minutes providing 7-8 feet of visual airflow – Request a Quote

The Cleanroom Fogger, CRF-2, is used in smoke studies and often referred to as a smoke generator, which is used to visualize airflow patterns and turbulence in clean rooms and pharmaceutical ISO 3, ISO 5, ISO 7 and ISO 9 suites. The CRF-2 will provide instant on/off operation as an airflow visualizer for smoke studies to monitor patterns and turbulence in controlled clean room areas.

Visualize airflow turbulence in smoke studies and smoke tests!

Fog volume is a primary requirement for a customer when purchasing a fogger. Fog density is usually unknown and not understood, but is the second most important reason for buying a fogger; as density controls the distance the airflow patterns and turbulence will be visible. Fog Volume is the second requirement. To calculate fog density, find out the actual fill volume of the fogger and the actual operational time of the fogger. Ultrasonic foggers use an ultrasonic transducer assembly under water, which then is powered to generate fog vapor that is pushed into the airflow to visualize patterns, turbulence and dead spots. Which ultrasonic fogger is the best for the money invested? Most ultrasonic foggers operate with 1 liter to 4 liters of water volume, when filled. The CRF2 has a fill level of 3.75 liters of DI Water or WFI water and provides a fog density of 57 ml per minute.
The Cleanroom Fogger is used in smoke studies for airflow visualization using Distilled or WFI Water to produce a pure fog to visually describer airflow, patterns and turbulence in semiconductor clean rooms, pharmaceutical ISO suites, bio-safety cabinets, compound pharmacies and medical rooms for contamination control. It is used in Pharmaceutical suites in support of USP 797 Pharmaceutical In-Situ Airflow Analysis and supports the proposed USP 800 for Hazardous Drug Compounding.

Cleanroom Fogger, CRF-2, producing 9 cfm of Pure Fog – Request a Quote

The CleanRoom Fogger, CRF2, is used in smoke studies and often referred to as a smoke generator, which is used to visualize airflow patterns and turbulence in clean rooms and pharmaceutical ISO 3, ISO 5, ISO 7 and ISO 9 suites. The CRF-2 will provide instant on/off operation as an airflow visualizer for smoke studies to monitor patterns and turbulence in controlled clean room areas.

CleanRoom Fogger, CRF2 Features – Click here for Cleanroom Fogger Video

Cleanroom Fogger
  • 9 high performance piezo ultrasonic devices converting DI Water or WFI water directly to 9cfm of of pure fog for about 50 minutes
  • Quick refill of Di Water or WFI water for continuous fog use, Easy to Fill Water Port and Water Level Indicator on left side of fogger
  • Cleanroom Fogger Handle for easy carry convenience
  • Polypropylene white enclosure provides a clean and particulate free enclosure, no finger prints, less weight
  • Transducer life is 3000 hours
  • Fog Curtain Wand, optional, plugs into end of Fog Hose to create a wide fog wall, while reducing the fog velocity and maintain a constant 9cfm of fog output
  • 2″ Diameter (5.08 cm) hose that telescopes from 28 inches to 82 inches
  • Fog Tube and 120VAC Power Supply (or 220VAC) is included, 15 foot power cable
  • Easy to use, quick operation set up, instant On/Off fogging operation
  • Rolling Carry Case, optional, for carry and storage of Clean room Fogger
  • Remote Power Cable with ON/OFF switch to operate fogger behind closed walls or in a barrier isolator
  • Paperless operation – instructions and applications on the right side of the cleanroom fogger

cleanroom Fogger and fog curtain wand

Cleanroom Fogger, Pharmaceutical Suites, Semiconductor Clean Rooms

  • Supports Recovery Test evaluation, 100:1 recovery time as defined in ISO 14644-3
  • Supports airflow visualization tests for ISO 14644-3 ANNEX B7
  • Supports airflow visualization analysis for Pharmaceutical USP 797 Guidelines
  • Supports airflow visualization tests for NSF 49 National Safety Foundation
  • Supports airflow visualization tests for the future USP 800 Hazardous Drug Compounding
  • Supports airflow visualization tests for Semiconductor Semi-Standards Guidelines
  • Air flow balance
  • Leak detection of exhaust ducts
  • Barrier Isolator and laminar flow tests
  • Wet bench exhaust tests
  • Personal safety exhaust tests
  • Chemical process equipment, exhaust ventilation tests
  • Pressure balancing between rooms and spaces
  • Visualization of airflow patterns and turbulence

CRF-2 Cleanroom Fogger– Request a Quote

CRF2 CleanRoom Fogger
FOG Duration up to 50 minutes
FOG Volume 9 cubic feet per minute with 57 ml fog density per minute
Total FOG Volume 540 cubic feet of pure fog over 60 minute operation cycle
Visible Fog Distances 7-8 feet
FOG Type Pure Fog using DI Water WFI Water
Class of Clean Room Class 1 to 10,000
Type of Room Clean Room, Sterile Room, ISO Suite, Medical Room
Water capacity 3.75 liters
Useable Water capacity 2.85 Liters
Liquid Weight 3.64 kg (8 lb.) Water
Power Requirements 115 VAC, 60 Hz, 14A
Optional Power 230 VAC, 50 Hz, 8A
Metric Dimensions, (H x W x D) 25.4cm x 22.9cm x 27.9cm
US Dimensions, (H x W x D) 10 inches x 9 inches x 11 inches
Empty Weight 5.45 kg (12LBs.)


The CleanRoom Fogger is used in smoke studies as a smoke generator. It is a significant improvement over other fog generators by providing a high fog volume for the low cost. Product weight is reduced by using a polypropylene enclosure. And operation instructions are located on the right panel, so there is no paper manual required in a cleanroom or around fume hoods or barrier isolators.

Theory of Operation: Ultrasonic cavitation and DI water or Pharmaceutical WFI Water. Use of any other liquids or chemicals will void the warranty.

The transducer life is ~5,000 hours. To protect the transducers from damage there is a level sensor that will interrupt the input voltage to the transducer module, should the water level drop to a low level. This ensures long life and reliability.

  1. The fog generated by this device contains microscopic droplets of DI water. AVOID USING IN IMMEDIATE VICINITY OF ELECTRICAL APPLIANCES, WATER SENSITIVE PRODUCTS AND EQUIPMENT.
  2. The fan will operate with no water in the reservoir with the power switch in the ON position. This will aid in drying when the chamber is drained.
  3. To increase drain plug tension, remove the plug, rotate clockwise (CW) the front latch while holding the rear metal disk.
  4. The CRF-2 is intended to be used on a flat surface, on its feet. Tipping the enclosure with water in the water reservoir will damage the unit. DO NOT OVERFILL OR TIP THE FOGGER.

Which Clean Room Fogger or Smoke Generator Is Best For My Applications?

Cleanroom UltraPure Fogger, AP35, 5 Cubic Meters / min, 533 ml fog density / minute for 75 minutes, 20-30 feet visible airflow.
  • When high fog purity, high fog volume and long visible airflow is needed in typical sized clean rooms
  • To visualizing airflow in large clean rooms, ceiling to floor
  • To fog exit velocity must not create turbulence
  • To needing to do 3D airflow modeling of airflow
  • When needing to do visualize airflow in larger cleanrooms
  • When 75 minutes of high purity fog duration is needed
  • When fog visibility of 20-30 feet distance is required
  • To fog Class 1 to Class 10,000 semiconductor, medical, pharmaceutical clean rooms

* Use Hand Gloves and Face Shield when filling LN2
Use 16 Meg ohm DI water or WFI water for injection

Cleanroom Fogger, CRF2, 0.26 Cubic Meters / min, 57 ml fog density / minute for 50 minutes, 7-8 feet visible airflow.
  • When budget is low, basic Fogger OK
  • When 50 minutes of fog duration is useful with quick turnaround
  • When fog visibility for 7-8 feet distance is acceptable
  • When fogging gray areas behind the clean room
  • When fogging ≥ Class 10 or above in semiconductor or pharmaceutical clean rooms
CRF4 Di Water Fogger, 1.25 Cubic Meters / min, 170 ml fog density / minute for 45 minutes, 10-15 feet visible airflow.
  • When higher fog volume is needed but LN2 is not desired
  • When fog visibility of 10-15 feet distance is acceptable
  • When 45 minutes of fog duration is useful
  • When fogging smaller clean rooms, barrier isolators
  • Class 10 or above in semiconductor or pharmaceutical clean rooms
  • When needing direct fogger control or wireless remote control

Use 16 Meg ohm DI water or WFI water for injection
Do not permit DI Water to go stagnant in the chamber
** Use gloves when handling CO2 ice

Fogger Technology

The three types of foggers manufactured for use in the semiconductor and pharmaceutical industry are described below.

Ultrapure LN2 Fogger: This type of smoke generator or clean room fogger has been in production from 2001 and provides the highest volume, highest density and highest purity of fog. Purity is created by bringing the water to a high temperature, creating a vapor, while simultaneously using gravity and ground to remove the residual mass from the vapor. This process removes any bacterial agents and residual particulate matter from the vapor. The pure vapor is then passed over an LN2 bath, which naturally boils at room temperature. The water molecules bond with nitrogen molecules, creating a very high density, nominal 3um fog droplet. The volume of water and nitrogen molecules that combine is extremely high in quantity, creating a dense, high volume, ultrapure fog output with exit temperatures of about 78 degrees F with an exit pressure of less than 0.5 lbs, so as not to disturb the surrounding airflow. The fog is ultrapure leaving minimal, if any, trace particles behind. It evaporates to its gaseous hydrogen, oxygen and nitrogen components, which are natural to the clean room environment. The high density of the fog increases the duration and travel distance of the fog. The CRF2 fogger can be used in a Class 1 – 10,000 clean room environments of pharmaceutical and semiconductor facilities; such as sterile rooms, hospital rooms, medical rooms and clean rooms.

DI Water Fogger: This type of fogger has less fog density (less capability to visualize airflow) than the Ultrapure Fogger described above, but more density than the CO2 fogger described below. The DI water fog is generated by atomizing DI water into water droplets, which are nominally 7-10um in size. The water droplets may contain residual particulate matter remaining in the DI water, but this would be very trace amounts. If the facility manager operates a class 10 to Class 10000 Clean room, the use of a DI Water Fogger poses no problem. However, Cleanroom Engineers who manage facilities operating at Class 1 to Class 10 performance may desire to use an ultrapure fogger. Although some DI Water foggers are described as ultrapure, unless the DI water is vaporized to remove bacterial agents and residual particulate matter, the fog is not ultrapure. The fan output of a DI water fogger can distort airflow patterns, if you push the fog against the airflow. The typical 68 degree F temperature of fog at the output is typically less than the surrounding room temperature, thus a fog generated from the atomized water droplets will sink momentarily in a typical 70 degree room temperature.

CO2 Fogger: This type of smoke generator or CO2 Fogger is designed for low volume, non-process critical applications such as bench airflow testing. The fog is created using CO2 ice as the fogging agent. The fog contains elements of the CO2 and the user must determine if the residual CO2 components are acceptable in a process environment operating Class 100 to Class 10,000. The output starts at about 3cfm and slowly decreases to 0 CFM in about 10 minutes.

Smoke Sticks

Smoke Sticks are used in some Pharmaceutical Clean Rooms around the world. Below is a discussion on the use of smoke sticks used to visualize airflow and turbulence?

A smoke stick is often used visualize airflow turbulence, but smoke sticks are filled with particulates and chemicals. Smoke is created using chemical reactions; thus the smoke is SPUTTERING (sputter) or popping out of the smoke stick in a non-consistent pattern with velocity, but little volume. It is a particle smoke, compared to a visible, pure water based fog, thus smoke sticks are a contaminating smoke. The smoke stick generates an inconsistent flow or pattern of smoke, but it is low cost, which is why some managers allow use of smoke sticks in their Pharmaceutical clean rooms.

Compare a smoke stick to a Clean Room Fogger or an UltraPure LN2 fogger, both which produce a constant volume of fog with a consistent fog output and pure fog. Di Water foggers produce a consistent flow of visible water vapor, which enters the airflow to visualize the airflow patterns and turbulence, then begins to evaporate, returning back to the hydrogen, oxygen and nitrogen components that we breathe. No particulate contamination, no chemical contamination. Water based foggers produce a constant volume of fog at a constant rate, which provides consistent visualization of airflow patterns and turbulence. The Smoke Stick has to be waved around to see what kind of airflow pattern there is, while a Di Water fogger is simply placed in position and produces a flow of fog that can be directed 360 degrees to easily describe the airflow patterns and turbulence. In addition, tubes are now available to create “fog curtains”, or a wall of fog, which smoke sticks can not produce.

How many smoke sticks are used per smoke cycle? How much labor is needed to clean up after smoke stick use. Do you need to Clean all the walls where the smoke stick was used. How did the chemical particulates and particles affect the process area? These are critical questions for a pharmaceutical manager. Did the contaminating particles and chemicals get into the drug process?

How much labor is used to cleanup after smoke stick use and if the cleanup did not get every chemical particle, then some smoke chemical material is added to the Pharma process or trapped in a filter somewhere, until it escapes into the Pharma process. That is a quality control issue for that company using smoke sticks.

The low labor cost of using smoke sticks is the reason facility managers may use smoke sticks, but are the chemical and particulate effects to the pharma process being analyzed? Non-contaminating fog does not emit particulates, requires less labor and does not contribute any unwanted chemicals to the Pharma process. A Di Water Fogger provides these advantages in fog volume, fog consistency and fog purity, which easily outweighs the low cost of smoke sticks, the high cost of labor for cleanup and the detrimental affects to quality control!

Smoke Sticks – quality side of the drug product: The smoke chemicals are not of the same chemistry as the drug product, thus smoke chemicals and particulates could migrate into the drug process. There is no guarantee the cleaning process removed all the unwanted particulates and chemicals, from for example, a glove box or isolation box. The chemicals and particulates eventually migrate to the air filter system, which is not 100% effective. If this is the case, the quality and purity of the drug process is affected. Drug quality is the basis of product credibility, which is a valuable asset in customer relations.

Smoke Sticks – labor side of the drug product: The smoke is generated by a chemical reaction, which causes the smoke to sputter into the environment. The smoke is inconsistent in volume, thus the smoke stick is unpredictable for airflow visualization. The chemicals migrate to equipment and walls, which then must be cleaned, and requires an added labor cost. The use of Smoke sticks generates an inefficient smoke, not a consistent fog.

Glycol Foggers – Glycol foggers use Deionized water or WFI water combined with a glycol liquid. Glycol foggers would normally be used in industrial clean rooms, rather than semiconductor clean rooms or pharmaceutical sterile rooms. Glycol produces excellent visible fog; but the long strand molecules can degrade HEPA filters by clogging the filter material. This can reduce airflow efficiency with resulting odors emanating from the filter into the airflow. Glycol fog residue needs to be wiped clean, requiring more labor and manpower. In a pharmaceutical process, how does the facility manager clean 100% of the glycol residue from the clean room and how much glycol residue enters into drug process? For this reason, glycol foggers would normally be used in non-critical, industrial clean rooms to search for airflow leaks, etc.

Although Smoke Sticks and Glycol may be much less expensive in use, the resulting clean up may be prohibitive. A Di Water Fogger produces water (H2O) droplets that evaporate back into hydrogen and oxygen, the air we breathe. No clean up is required, at all. No additional time delays and clean up labor is not required. The fog is consistent in volume and constant in output to describe the airflow patterns and turbulence. These are equipment, quality and application concerns to consider when the need for airflow visualization is considered.

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